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Triggers of IL-1 production have been observed in a number of different stimuli, such as sulfur mustard, nickel, contact allergens or superantigens 36 IL-1 stimulates further release of secondary mediators, including IL-8

2014 Aug;7(8):796-804

Current research limitations include the absence of large-scale randomized clinical trials in humans, an still partial understanding of the precise molecular mechanisms, and a lack of detailed pharmacokinetic data in humans

This is incredibly relevant here, as studies indicate a rising prevalence of fatty liver among urban Indians due to refined carbohydrate and seed oil consumption

Houstis, N., Rosen, E