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Abbreviations BMMCs: Bone marrow derived mast cells DAPI: 4,6-Diamino-2-phenylindole ET: Extracellular trap GAS: Group A Streptococcus H3Cit: Citrullinated histone H3 HIF-1: Hypoxia-inducible factor 1 HMC-1: Human Mast cell line-1 HMDM: Human monocytederived macrophage mAb: Monoclonal antibody MCETs: MCs extracellular trap mDCs: Myeloid dendritic cells MPO: Myeloperoxidase NOD: Nucleotide-binding oligomerization domain PAD: Peptidyl arginase deiminase PAD: Peptidyl arginine deiminase PMA: Phorbol-12-myristate-13-acetate RIG-I: Retinoic acid-inducible gene I ROS: Reactive oxygen species RSV: Respiratory syncytial virus NLRP3: NOD-like receptor protein 3 ASC: Apoptosis-associated speck-like protein References Kenny EF, Herzig A, Krger R, Muth A, Mondal S, Thompson PR, Brinkmann V, Bernuth HV, Zychlinsky A (2017) Diverse stimuli engage different neutrophil extracellular trap pathways

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These effects were dose-dependent and generally subsided as the body adapted to weekly dosing schedules

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