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In a HA- hydrogel containing resveratrol-loaded (10 mg) chitosan (CS) nanoparticles, release of resveratrol was observed, and it counteracted oxidative damage that was induced by ROS generation in a TNF-/IFN--treated (AD-like) human keratinocytes, without induction of cell death [191]

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ii) Utilizing the steric hindrance conferred by dimerization reduces protease access to the active site and significantly improving stability against proteases 49,50

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