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Additional regional factors such as high baseline HBV endemicity (5-18%), dietary aflatoxin exposure, and lower NAFLD prevalence further limit direct extrapolation (105)

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In the LIPO-010 trial, a randomized, double-blind, placebo-controlled study, tesamorelin reduced visceral adipose tissue by 19.6% over 26 weeks compared to placebo

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Its imbalanced receptor affinity and biased signaling provide enhanced insulin secretion and improved metabolic outcomes beyond selective GLP-1 agonism