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Furthermore, the group treated with GLP-1-R agonists experienced fewer headache days than the other group while the dose of acetazolamide was reduced

These agents enhance glucose-dependent insulin secretion from pancreatic beta cells, suppress inappropriate glucagon release, slow gastric emptying, and promote satiety through central nervous system pathways

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Any effect on GLP-1 appears to be indirect and secondary, with the evidence remaining limited and inconsistent

The takeaway: berberine has a legitimate, research-backed role in supporting healthy blood sugar for people looking for a natural option, but it is not a diabetes treatment and should never replace prescribed medication