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In cell culture experiments, three critical factors should be kept in mind: the compound stability (40), concentrations used and whether unconjugated compounds or physiologically abundant phase II conjugates are used for most meaningful results (41, 42)

Allouh M Z, Rizvi S F A, Alamri A, et al

doi: 10.1126/science.abf0529 283 TmerZ.MllerL

The agency also signaled plans to lower allowable workplace exposure levels to 0.1 parts per million by 2035, citing evidence that the chemical may be up to 60 times more dangerous than previously estimated

C32 is the second active-site cysteinyl residue of PfGrx and C88 is the third cysteinyl residue, which is in the proximity of the active site and can also undergo redox modifications 14,26,30