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[PMC free article: PMC3795900] [PubMed: 23954640] [CrossRef] 20

The researchers found that subjects receiving just five low doses of MT-II (0.025 mg/kg) administered subcutaneously every other day experienced measurable increases in skin pigmentation

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Besides an increased homocysteine export from tissues into plasma that may be regulated by a reduced-homocysteine carrier (Blom, 2000), hyperhomocysteinemia can result from reduced renal function, which may have a central role in plasma homocysteine clearance, and from chronic hepatic insufficiency

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