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The Lancet Frias JP, et al

Besides the acute phase gastrointestinal effects which may lead to up to 10% of people discontinuing the drugs, there are other potential GI side effects of obstruction, excessive loss of muscle mass, and potentially association with some eye disease adverse events

There is a rare effect on the nerves and muscles with long-term use of colchicine, and a blood test from the muscle (CPK) is monitored at approximately six-month intervals in patients taking colchicine on a regular basis

Muscle Recovery Animal models demonstrate accelerated muscle healing after crush injuries, lacerations, and systemic damage

A gut-specific pairing that combines a mucosal "repair" peptide with a targeted anti-inflammatory tripeptide, marketed for leaky gut, IBS, and IBD/colitis-adjacent symptoms rather than the tendon/ligament use case BPC-157 is better known for