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The article will need updating if FDA issues a decision or Novo Nordisk changes its development plan

GSH depletion-dependent cell death was prevented by selective ferroptosis inhibitors (8 M Fer-1 and 600 nM Lip-1), iron chelator DFO (80 M), as well as autophagic inhibitors Baf-A1 (75 nM) and 3-MA (10 mM)

[] In rats, apoptosis induced by cisplatin and HIP oxidative stress were decreased by supplementing cisplatin with NAC

10.18632/aging.102682 Aging Summary Keywords chondrocyte, senescence, autologous chondrocyte implantation, senolytic , FOXO4-DRI Citation Huang Y, He Y, Makarcyzk MJ and Lin H (2021) Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes

31,32 The primary site of impact is the small intestine, where poor absorption of various nutrients including vitamin B 6 can occur