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In agreement with these data, we have observed that UDCA alone improves the intestinal Ca 2+ absorption by increasing the amount of Ca 2+ transporters involved in the transcellular Ca 2+ pathway via activation of the VDR gene and protein expression

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Early Cellular-Level Changes (Preclinical Findings) The earliest documented changes occur at the molecular level, within hours of receptor binding, and are not observable without laboratory measurement

For example, if an REH elects to report the Emergency Care Access & Timeliness eCQM, the first proposed reporting period would run from January 1, 2027, through December 31, 2027, with a submission deadline of May 15, 2028

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