Ridha Z et al, Aesthetic Surgery Journal 44(11):NP809-NP818, PMID 38874170) describes GLP-1 receptors on adipose-derived stem cells (ADSCs) and fibroblasts in skin, and proposes that activation of these receptors may reduce protective cytokine production from ADSCs, increase oxidative stress on neighboring fibroblasts, reduce ATP production through altered glucose uptake, and indirectly reduce local estrogen production from dermal white adipose tissue
Most commonly, this means insulin through multiple daily injections or an insulin pump, though some providers use metformin as an adjunct since its generally considered safe in pregnancy
References: EMC SmPC Ozempic (semaglutide)
Quick summary Reconstituting a peptide means dissolving freeze-dried powder into bacteriostatic water so every dose can be measured the same way
However, research on GLP-1s cognitive and neuroprotective roles has largely been conducted in males