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The cerebral cortex was selected for discovery proteomics due to its larger tissue mass, which ensures the high yield and quality of protein required for a robust DIA-MS workflow

In addition to the relevance of POP conjugation cited previously, hyperglycemia and hyperinsulinemia appear to directly inhibit glutathione synthesis (GCL), and the increased production of reactive oxygen species which accompanies diabetes further depletes GSH levels

Metabolic benefits build gradually with consistent treatments

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