Liver-specific catalase expression in transgenic mice inhibits NF-kappaB activation and DNA synthesis induced by the peroxisome proliferator ciprofibrate
All the biological mechanisms result in a neuroprotection increase and lead, as a consequence, to a reduction of migraine headaches frequency, migraine pain reduction, and alleviation of the aura symptoms (red arrow on the right side of the graph)
Indeed, assessments of functional phagocytic differences under conditions that more closely replicate the in vivo state (i.e., in media consisting of autologous PD sera) indicate increased, rather than reduced, beadphagocytic capacity, contrasting with results obtained after prolonged incubation in artificial media [111]
Additionally, this company helped fund the study, raising a potential conflict of interest
Holdsworth DA, Chamley R, Barker-Davies R, OSullivan O, Ladlow P, Mitchell JL, Dewson D, Mills D, May SLJ, Cranley M et al (2022) Comprehensive clinical assessment identifies specific neurocognitive deficits in working-age patients with long-COVID
