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Inhibiting SCD1 reduces the content of MUFA and increases the content of PUFA, which can provide a corresponding substrate for lipid peroxidation

Uric acid crystals can build up in multiple joints, but gout attacks are more common in lower limb joints such as the knees, ankles, and particularly the base of the big toe

RGCs are vulnerable to oxidative and inflammatory stressors and have been shown to be thinned in hyperglycemic conditions [8688]

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Another study found that patients' out-of-pocket spending on just disease-modifying therapies (DMTs) for MS increased from $18.9 million in 2006 to $149.4 million in 2016 [8]