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The Journal of clinical and aesthetic dermatology , 2 (12), 4448

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A recent comprehensive review notes that, while NMDA receptor antagonists have shown potential, the evidence from clinical research is mixed and insufficient to prove their general effectiveness for tinnitus (Che et al., 2025)

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Importantly, the consequences of chronic oral SAM administration on methyl metabolism are unknown, and the few existing studies have only looked at the immediate effects ( SAM