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Back Samols, E, Marri, G, Marks, V (1965) Promotion of insulin secretion by glucagon, Lancet , 40, 415-6

It can increase nausea, interfere with blood sugar control, and add empty calories that hinder weight loss

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Pretreatment with each examined GLP-1 analogs, including GLP-1(736), liraglutide, and exendin-4, led to significantly reduced Ca 2+ responses (by 53.8%, 58.1%, and 72.2%, respectively)

Once primarily a concern for high-income countries, excess weight and obesity is now widespread across many different regions, income levels and age groups, making it one of the worlds biggest public health concerns