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Routine B12 monitoring is not mandated for tirzepatide, but baseline and periodic testing should be considered for high-risk patients, including those over 65, on concurrent metformin, with gastrointestinal disorders, or experiencing symptoms such as fatigue, neuropathy, or cognitive changes

The combined effect of these changes likely explains the 50% decrease in total hepatic TG content in CON-fed KO mice

Without adequate choline, the liver cannot properly package and export fat, which can lead to fat accumulation in liver tissue

These activities decrease oxidative damage markers, which frequently relates to increased motility and decreased DNA fragmentation scores

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