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Patients on GLP-1 medications losing more than 2 pounds weekly often benefit most because rapid weight loss increases hepatic lipid flux and oxidative stress simultaneously

Per its FDA label, tesamorelin has a mean elimination half-life of roughly 18 minutes after a single subcutaneous dose and about 37 minutes with multiple dosing

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It is important to note that although these systemic anti-inflammatory effects are observed in both populations, the baseline inflammatory burden, semaglutide dose exposure, and degree of weight loss may differ between patients with T2DM and individuals treated primarily for obesity, which should be taken into account when interpreting mechanisms related to adipose tissue