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It's a mechanical problem

Lets look at the data Berberine has more than 70 clinical studies that are strong that suggest its efficacy. Faulstroh also cited the usage of berberine to treat diabetes in Ayurveda as a driving factor to create the supplement

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Additionally, lysosome-associated membrane protein 3 (LAMP3) is elevated within the salivary glands of specific individuals suffering from SS, and the resulting lysosomal dysfunction serves as a crucial factor in the evolution of the disease [280]

This is largely due to the presence of l-glutathione, a compound known to inhibit melanin production which causes darkening of the skin