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A combination of treatments will likely be necessary to address the issues in ME/CFS/FM Rather than directly implicating mitochondrial dysfunction , the three studies culminated with strong evidence supporting oxidative stress and associated pathophysiological consequences as the most likely neurobiological underpinnings of the observed elevations of ventricular lactate in ME/CFS [Shungu et al 2012]

10.3390/bios14070335 Biosensors (Basel) 6 AlipourM.Hajipour-VerdomB

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doi: 10.2527/2000.7841078x 84 MtayerS.SeiliezI.CollinA.DuchneS.MercierY.GeraertP