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Protecting Muscle & Bone Mass About 20%, up to 40% (Spreckley 2026) of total weight lost can come from muscle tissuesomething especially concerning for women in perimenopause or menopause, who are already losing lean mass with age

But tirzepatide should not be used as a substitute for prescribed blood pressure medication unless a healthcare provider makes that change

Participants taking the highest dose of retatrutide saw, on average, the following health improvements: these average reductions in cardiovascular disease risk factors: 37 percent reduction in triglycerides, or fats in the blood 16.5 percent reduction in non-HDL bad cholesterol 9.3 mmHg reduction in systolic blood pressure, the pressure in the arteries when the heart beats 7.5-inch reduction in waist circumference 51.2 percent reduction in high-sensitivity C-reactive protein, a measurement of inflammation in the body Side Effects Led More Than 1 in 10 Participants to Drop Out Side-effect rates differed between the two trials

Zepbound (tirzepatide) is an FDA-approved prescription medication indicated for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbid condition, such as hypertension, type 2 diabetes, or dyslipidemia

The coaching focuses on sustainable lifestyle changes rather than restrictive dieting approaches