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Protein degradation (proteasome activity, MG-132 assay): IGF-1 LR3 1824% (Akt-mediated FoxO1/3 phosphorylation suppressing Atrogin-1)

(2005, 2010) found increased CSF levels of the endogenous cannabinoid anandamide in untreated PD patients, which were unrelated to the severity of the disease (Pisani et al., 2005) and reversed by chronic dopaminergic replacement (Pisani et al., 2010)

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