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These conditions are the same as those seen in POMC-null mice

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found that in colon cancer, Gln deprivation stimulates p53 activation and promotes the expression of the aspartate/glutamate transporter SLC1A3, thereby promoting glutamate, Gln and nucleotide synthesis, maintaining electron transport chain and tricarboxylic acid cycle activity

And that 10mcg is four times the daily requirement

Diet and Fiber Diversity Dietary fiber supports beneficial bacteria that produce short-chain fatty acids essential for intestinal health