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When estradiol levels rise due to fat-driven aromatization or conversion of excess external testosterone the brain senses enough sex hormone and slows down the axis: Less GnRH is released from the hypothalamus The pituitary releases less LH and FSH The testes produce less natural testosterone This negative feedback loop means men with obesity or on high-dose TRT may experience further suppression of their own testosterone production and long-term dependence on therapy

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E., Needle, D., Chen, C

Antioxidant Protection: Glutathione neutralizes harmful free radicals in the body, which helps in preventing cell damage and reducing the risk of chronic diseases linked to oxidative stress, such as cardiovascular diseases and cancer

[PUBMED Abstract] Scher HI, Chung LW: Bone metastases: improving the therapeutic index