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A meta-analysis of 120 studies ( n = 125,446 patients) reported that most prevalent comorbidities for SARS-CoV-2 infection include: hypertension (32%), obesity (25%), T2DM (18%), and CVD (16%) 741

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Several other investigators have also revealed that the activation of IGF-1R stimulated the p53-dependent cellular senescence, e.g., in human and mouse fibroblasts, human mesangial cells, and rat vascular smooth muscle cells [144,145,146]

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The synergy of these 3 active ingredients contributes to improve the texture and tone of the skin, providing luminosity