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Over time, this energy shortfall sets off a cascade of downstream effects: synaptic dysfunction, impaired protein clearance, neuroinflammation, and ultimately the accumulation of amyloid- and tau pathology [5]

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[21] (starting dose 0.25 mg for 4 weeks, then 0.5 mg for 4 weeks and 1.0 mg for 5 weeks) and Nauck et al