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GSH administration was associated with shorter OS and DFS in breast cancer patients, with a median survival of 68 months in the GSH group, compared to 74 months in the Non-GSH group ( P = 0.023)

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In other words: if a researcher is studying IGF-1 LR3's effects on cell proliferation and the preparation is contaminated with endotoxin, the observed proliferation response could be driven by LPS rather than by IGF-1 LR3 signaling through IGF-1R