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Significant healing needs that affect quality of life may justify accepting theoretical risks that would be unacceptable for minor issues

Recent (albeit modest) successes with amyloid-clearing immunotherapies suggest that reducing the load of potentially pathogenic oligomers or higher-order aggregates may be beneficial, and at the same time provides proof-of-principle that these species are at least partially responsible for promoting the degenerative process (Jucker and Walker, 2023)