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[1] Patients should be educated about signs of worsening hyperglycemia (increased thirst, frequent urination, unexplained weight loss, blurred vision) that warrant prompt medical attention

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In addition, aldosterone, released upon the action of angiotensin II and sympathetic nervous system hyperactivation, reduces insulin sensitivity in several cell types triggering maladaptive responses in type 2 diabetes, hypertension, and HF (Aroor et al., 2012a)

Others may have been due to related issues (i.e

Reduced joint pain makes previously uncomfortable positions accessible again