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According to studies by Culhane et al., it appears to activate the GHRH receptors through several steps, which may involve the activation of an intracellular messenger called cyclic AMP (cAMP) and the kinase PKA (protein kinase A), which together may switch on the cellular machinery that synthesizes and releases hGH

Later, transcriptomic studies in A

The results indicated a significant increase in resting metabolic rate (RMR), with a 7.2% to 8.4% rise from baseline within 4 h post-intake

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