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The constituents of the MedDiet, such as essential omega-3 and 6 fatty acids, polyphenols, fibers, and vitamins, are reported to positively impact the molecular pathways associated with all recognized hallmarks of aging (Martinez-Gonzalez and Martin-Calvo, 2016

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In particular, combining 2-OHNA with other NAD + biosynthesis inhibitors like FK866 effectively kills NAPRT-proficient cancer cells resistant to single-agent treatments 217

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