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The mechanism of its pathogenesis is not fully understood, multiple parallel hits are believed to be involved, including insulin resistance, hormones secreted from the adipose tissue, nutritional factors, gut microbiota and genetic and epigenetic factors ( In recent years, more and more attention has been paid to intestinal flora and its metabolites

Mean absolute weight changes (kg), standardized mean difference (SMD) and 95% confidence intervals (CIs) were computed for these continuous variables (WL and WR)

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The lidocaine provides immediate, profound pain relief by blocking all local nerve signals