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Dose escalation in the phase 3 trial is designed to reduce the incidence of gastrointestinal adverse events when switching to monthly dosing
![gliptin and glp-1 Glucagon-like peptide-1 sitagliptin [TUSOM | Pharmwiki]](https://tmedweb.tulane.edu/pharmwiki/lib/exe/fetch.php/dpp4.png?w=600&tok=f9724b)
The science behind GLP-1 medications is strong
![gliptin and glp-1 Glucagon-like peptide-1 sitagliptin [TUSOM | Pharmwiki]](https://www.researchgate.net/profile/Eiji-Kutoh/publication/50890863/figure/fig2/AS:196024627929098@1423747321980/Schematic-presentation-of-glucagon-like-peptide-1-GLP-1-dependent-and-GLP-1-independent.png)
In the Chinese market, there are already 10 GLP-1-RAs authorized for sale
![gliptin and glp-1 Glucagon-like peptide-1 sitagliptin [TUSOM | Pharmwiki]](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9032/6696077/cc6dde43ce58/ijerph-16-02720-sch001.jpg)
For perimenopausal women, weight management becomes particularly challenging due to hormonal fluctuations that affect metabolism, appetite regulation, and body composition
![gliptin and glp-1 Glucagon-like peptide-1 sitagliptin [TUSOM | Pharmwiki]](https://www.researchgate.net/publication/260680847/figure/fig3/AS:513088665001985@1499341278619/Fig-3-Mechanism-of-action-for-GIP-GLP-1-analogues-and-DPP4-inhibitors-in-controlling.png)
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