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Advanced experimental models integrating vascular remodeling, BBB integrity, and neurovascular interactions are essential to accurately simulate the dynamics of chronic disease

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Nuclear receptor Rev-erb: up, down, all around

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Analyses of kidney outcomes in the original CVOTs prompted dedicated kidney outcome trials, of which two are completed: Evaluation of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Participants With Diabetic Nephropathy (CREDENCE, NCT02065791) and A Study to Evaluate the Effect of Dapagliflozin on Renal Outcomes and Cardiovascular Mortality in Patients With Chronic Kidney Disease (DAPA-CKD, NCT03036150)