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We observed no significant changes in the expression of p53 or p21 in keloid lesions or fibroblasts compared to those in normal skin

By reducing excessive Ca 2+ influx (a trigger of cell death) and preventing the release of pro-apoptotic factors like cytochrome c from mitochondria, schisandrins effectively decreased apoptotic cell death in this model (58)

Hierarchy of Evidence: Level D (Pre-clinical animal models)

The methylation pathway also leads to multiple other pathways (ie

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