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The trial enrolled 338 adults with obesity (BMI 30) or overweight with comorbidities (BMI 27) and ran for 48 weeks

As doses increased through the titration schedule, the proportion of participants experiencing nausea also increased, peaking in the 8 mg and 12 mg groups

For a 1 mL vial at 5mg/mL concentration (5 mg total): For a 2 mL vial at 5mg/mL concentration (10 mg total): The 2 mL vial provides significantly better value per milligram at higher doses

Metabolic/Systemic Effects Changes related to weight loss itself and hormonal shifts: fatigue, changes in energy, menstrual changes (in women)

NICE Guideline NG211