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Stability is not judged by appearance alone

Chiu ST, Hsieh FJ, Chen SW, Chen CL, Shu HF, Li H

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This plateau is known as the steady-state concentration, ( C ss ) At steady state, a dynamic equilibrium is achieved where the amount of drug administered during a dosing interval is exactly equal to the amount of drug eliminated during that same interval

FOXO4-DRI is a large peptide (~5382 Da, 48 amino acids) with a critical structural modification: the D-Retro-Inverso (DRI) design uses D-amino acids in reversed sequence to confer protease resistance while maintaining the 3D spatial arrangement needed for target binding