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For these patients, a GLP-1 that produces large rapid weight loss without a muscle preservation strategy is trading one metabolic problem for another
This combination of a manageable safety profile and an ethical trial design that prioritizes patient outcomes is encouraging for future clinical adoption and real-world application
In 2023, Fractyl Heath announced mice given semaglutide and treated with its gene therapy Rejuva, administered directly to the pancreas, had maintained a 22% weight loss for 28 weeks after stopping the drug and performed better than those given only semaglutide
Glucagon and energy expenditure
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