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First, the two core mechanism papers establishing the HGF/c-Met story (Kawas 2012, PMID 22129598

Nutrient Metabolism: Vitamin B12 supports the metabolic function of essential nutrients in your dog, especially fat and protein

Biomed Pharmacother 130:110523 Knudsen LB, Hastrup S, Underwood CR, Wulff BS, Fleckner J (2012) Functional importance of GLP-1 receptor species and expression levels in cell lines

The article lists options a provider may consider, including dose reduction, slower titration, increased hydration, electrolyte supplementation, or concurrent migraine prophylaxis, before discontinuation is considered