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Under normal conditions, the tyrosine at position 18 (Tyr18) in the LIR region in FUNDC1 and the serine at position 13 (Ser13) close to the LIR is highly phosphorylated, at which time FUNDC1 has a low affinity for LC3 [62]

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A low-carbohydrate diet serving 43% of total caloric intake over 16 days resulted in notable decreases in fasting and post-exercise insulin levels, implying a promising short-term dietary manipulation [81]

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