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Description

[6] The GLP-1 component plays a central role in appetite suppression, acting on receptors in the central nervous system to reduce food-seeking behaviour and increase feelings of fullness after eating

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A PBPK model of tirzepatide in adults was developed and verified by comparing the simulated plasma exposure with the observed data using PK-Sim&MoBi software

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The SPR and recombinant-protein assays provide stronger evidence for a direct interaction than the earlier pathway studies

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Lin A, Liu S, Wei H

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