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The research rationale established by NNMT-knockdown studies in diet-induced-obese mice is that inhibiting NNMT preserves intracellular NAD+ and SAM levels, which in adipocyte (fat-cell) models has been shown to suppress de novo lipogenesis

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Currently, it is unfortunately that the existing studies regarding vitamin B2 and bone health mainly focus on in the field of basic research, while clinical studies based on large population to explore the relationship between dietary vitamin B2 intake and bone loss are limited