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Also, in vitro studies indicate that the responsiveness of pro-B cells to IL-7 is compromised in aged individuals [355], and IL-7 release from stromal cells in the bone marrow also declines with age [356], leading to reduced pro B-cell proliferation
98 In extrinsic-mediated pathways, p53 regulates the expression of Fas and KILLER/DR5 on the cell membrane, and then, caspase-8 is activated, resulting in apoptosis
It might have an unglamorous name, but its backed by a substantial body of preclinical evidence across various tissue healing scenarios
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