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These peptide switches have been utilized to functionalize alginate hydrogels, where they rearrange upon enzymatic cleavage to expose the YIGSR sequence, which binds to integrins on the cell membrane

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A clinical study found that 80% of obese PCOS patients unresponsive to lifestyle changes achieved at least 5% weight loss on semaglutide (Wegovys active ingredient), with 80% of those normalising their menstrual cycles

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