An in vitro study indicates that agomelatine can suppress the upregulation of AT1R expression in HUVECs and the human monocytic leukemia cell line THP-1 cells, and reduce the adhesion of monocytes to ECs, a process involved in the early stages of atherosclerosis
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These infections not only diminish quality of life but also impose a substantial socio-economic burden, with billions of dollars spent annually on treatment and disability support
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In the United States alone, the annual direct medical costs associated with RA are estimated to exceed $19 billion, with indirect costs such as lost productivity further amplifying the economic impact 5
