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Across these trials, acute pancreatitis was rare, occurring in fewer than 0.1% of tirzepatide users compared to similarly low rates in placebo groups

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174 Previous studies have reported the comprehensive effects of GLP-1RA on the CNS, which go beyond the levels of blood glucose modulation, but are associated with numerous metabolic aspects such as food intake and preference, 127,175 water intake, 176 energy expenditure, 177 body weight reduction, 178 pancreatic function, 132,179,180 hypertension, 181 stress, 182 addiction behaviors, 183,184 as well as neurodegenerative disorders, such as Alzheimer and Parkinson diseases

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A partial somatostatin agonist bearing a close structural relationship to a potent, selective substance P antagonist