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Fer-1 Fer-1, the first synthetic ferroptosis inhibitor, has served as a pivotal reference compound (27)

Falagas, M., et al

The integration of fatty acids into membrane-bound lipids is believed to be vital for ACSL-dependent actions to modulate ferroptosis and convert fatty acids into CoA esters

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Paeoniflorin, another major blood-entry metabolite of DSS, has also been shown to activate the TRPA1 channel and the PLC-1/PIP2 signaling pathway to promote 5-HT release, thereby modulating tryptophan metabolism (Zhan et al., 2021)