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Understanding what each receptor does explains why simply reducing peak concentrations through split dosing may not be a straightforward improvement
In the longer-term (i.e., 4 weeks), intragastric administration of DB remained effective at increasing meal-induced GLP-1 secretion, associated with a reduction in body weight in obese mice, whereas another bitter tastant, quinine, had minimal effect on GLP-1 or ghrelin, despite reducing body weight (66)
Tirzepatide is a dual agonist: it activates the GIP and GLP-1 receptors
Alicia M
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