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SKI-178: a multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models

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Same dose schedule, same biological effect

The frozen sections were rehydrated with phosphate-buffered saline (PBS) and then blocked with PBS containing 1% normal mouse serum, 1% bovine serum albumin, and 0.3% Triton X-100, followed by staining with directly conjugated antibodies for 24 h at room temperature in a dark, humidified chamber

It can also increase the speed of recovery between maximal efforts by generating ATP more quickly