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It is commonly investigated in preclinical research models relating to peptide signalling pathways, cellular communication mechanisms, and copper-associated biological processes

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Recent findings suggest that many of the memory enhancing effects originally attributed to AngII acting at the AT1 receptor subtype were due to the conversion of AngII to angiotensin III (AngIII) and then to the hexapeptide angiotensin IV (Ang IV) and it were AngIV activation of the AT4 receptor subtype that facilitated memory consolidation and retrieval [62-64]

However, it is important to understand that 24 weeks, while substantial for clinical trials, provides limited information about safety with years-long continuous use

J Hepatol 2016;64:S173-4